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AssigneesRijksuniversiteit Groningen, Academisch Ziekenhuis Groningen
InventorsAlina SIGAEVA, Siyu FAN, Yue ZHANG, Arturo ELÍAS LLUMBET, Maria Margarida DIAS CARMONA LOBITA, Mohammad-Ali SHAHBAZI, Hélder ALMEIDA SANTOS, Romana SCHIRHAGL
Estimating the term…
A microneedle assembly (10) for delivering fluorescent nanocrystals (FNC) into a tissue (T) comprises one or more microneedles (11). Each microneedle (11) comprises a plurality of fluorescent nanocrystals (FNC) dispersed throughout a solid matrix material (11m). The tissue (T) can be penetrated with the one or more microneedles (11) and at least part of the matrix material (11m) can be dissolved inside the tissue for delivering the fluorescent nanocrystals (FNC) into the tissue (T). Various aspects of the tissue (T) can be measured by delivering light pulses to the tissue (T), and measuring a resultant fluorescent signal (Sf) from the fluorescent nanocrystals (FNC) inside the tissue (T). The microneedle assembly (10) can be, for example, manufactured using micro-molding techniques using a liquid precursor of the matrix material (11m) with a concentration of the fluorescent nanocrystals (FNC) in the liquid precursor.
A method comprising:
A method of manufacturing a microneedle assembly, the method comprising:
A microneedle assembly comprising a substrate with an array of microneedles for penetrating a tissue, wherein each microneedle is formed of a biodegradable solid matrix material with a plurality of fluorescent nanocrystals dispersed throughout the solid matrix material.
Dependencies are inferred from the claim text.