Systems and methods for determining crosstalk coefficients
AssigneeRoche Sequencing Solutions, Inc.
InventorRonald Kurnik
Life of this patent
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Abstract
The present disclosure relates to determining crosstalk coefficients for an analyzer based on customer data. In an aspect, a method includes obtaining a manufacturer defined temperature matrix for an analyzer. The method also includes obtaining a customer defined temperature matrix. The method also includes generating a custom temperature dependent crosstalk matrix for a customer. The method further includes performing, based on the custom temperature dependent crosstalk matrix, a matrix inversion and dot matrix multiplication to generate a crosstalk corrected customer fluorescence vector. The method further includes modifying manufacturer defined temperature dependent crosstalk coefficients on the analyzer based on the crosstalk corrected customer fluorescence vector.
Claims9
A method comprising:
- obtaining a manufacturer defined temperature matrix for an analyzer;
- obtaining a customer defined temperature matrix;
- generating a custom temperature dependent crosstalk matrix for a customer;
- performing, based on the custom temperature dependent crosstalk matrix, a matrix inversion and dot matrix multiplication to generate a crosstalk corrected customer fluorescence vector;
- and
- modifying manufacturer defined temperature dependent crosstalk coefficients on the analyzer based on the crosstalk corrected customer fluorescence vector.
A system comprising:
- a memory;
- and
- a processor coupled to the memory and configured to:
- obtain a manufacturer defined temperature dependent crosstalk matrix for an analyzer;
- obtain a customer defined temperature matrix;
- generate a temperature dependent crosstalk matrix for a customer;
- perform, based on the temperature dependent crosstalk matrix, a matrix inversion and dot matrix multiplication to generate a crosstalk corrected customer fluorescence vector;
- and
- modify the manufacturer defined temperature dependent crosstalk coefficients on the analyzer based on the crosstalk corrected customer fluorescence vector.
Dependencies are inferred from the claim text.