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US 2026/0286452 A1Published application
Compositions and methods for detecting group b streptococcus nucleic acid
AssigneeGen-Probe Incorporated
InventorsBarbara L. EATON, Benjamin GROBARCZYK, Yves OZOG, Renaud CLOSE, Laurent FRANZIL
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Abstract
Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for detection of Group B Streptococcus (GBS; Streptococcus agalactiae) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
Claims22
A composition for determining the presence or absence of Group B Streptococcus (GBS) in a sample, said composition comprising:
- (A) an amplification oligomer combination comprising first and second CFB-specific amplification oligomers capable of amplifying a target region of a GBS CFB target nucleic acid, wherein the first CFB-specific amplification oligomer comprises SEQ ID NO:18 or an RNA equivalent or DNA/RNA chimeric thereof and the second CFB-specific amplification oligomer comprises of SEQ ID NO:15 or an RNA equivalent or DNA/RNA chimeric thereof;
- and
- (B) an amplification oligomer combination comprising first and second SIP-specific amplification oligomers capable of amplifying a target region of a GBS SIP target nucleic acid, wherein:
- (a) the first SIP-specific amplification oligomer comprises SEQ ID NO:3 or an RNA equivalent or DNA/RNA chimeric thereof and the second SIP-specific amplification oligomer comprises SEQ ID NO:4 or an RNA equivalent or DNA/RNA chimeric thereof;
- or
- (b) the first SIP-specific amplification oligomer comprises SEQ ID NO:7 or an RNA equivalent or DNA/RNA chimeric thereof and the second SIP-specific amplification oligomer comprises SEQ ID NO:8 or an RNA equivalent or DNA/RNA chimeric thereof.
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Dependencies are inferred from the claim text.