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AssigneeSana Biotechnology, Inc.
InventorsMatteo STOPPATO, Kyle Marvin TRUDEAU, Zachary P. FRYE, Jagesh Vijaykumar SHAH, Jack REILLY
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Provided herein are lipid particles, such as lenti viral particles, that incorporate or are pseudotyped with paramyxovirus envelope attachment glycoproteins as fused to at least one component of a universal adapter system, and in some aspects also a fusion (F) protein such as a NiV-F protein or a biologically active portion or variant thereof. The present disclosure also provides for preparation of the lipid particles, such as lentiviral particles, comprising at least one component of the universal adapter system, as well as methods for preparing and using the lipid particles, such as lentiviral particles.
A lipid particle, comprising:
A lipid particle, comprising:
A paramyxovirus envelope attachment protein with a targeting moiety attached via a universal adapter system, said system comprising a tag polypeptide component and a catcher polypeptide component, wherein the paramyxovirus envelope attachment protein is fused to one of the components, and the targeting moiety is fused to the other of the components.
A paramyxovirus envelope attachment protein comprising one component of a universal adapter system with a targeting moiety attached via a universal adapter system, said system comprising a tag polypeptide component and a catcher polypeptide component, wherein the paramyxovirus envelope attachment protein is fused to the one component.
Dependencies are inferred from the claim text.