Gene delivery vehicles comprising RNA and antibodies

A combination of two or more gene delivery vehicles comprising:

• a first gene delivery vehicle comprising a first expression cassette comprising at least one nucleic acid comprising a sequence encoding a first RNA and a sequence encoding a second RNA, wherein the second RNA comprises a guide sequence and wherein the first and second RNA each comprise a hairpin;
• and
• a second gene delivery vehicle comprising a second expression cassette, comprising a transgene encoding a full-length mAb or an antigen binding fragment thereof,
• wherein the guide sequence is substantially complementary to a target sequence in a gene associated with a disease and wherein the mAb or antigen binding fragment thereof is targeting a protein associated with that same disease.