Compositions and methods to modulate idiopathic pulmonary fibrotic associated long noncoding rnas
AssigneeHAYA Therapeutics SA
InventorsHeather D. LYNN, Rudi MICHELETTI, Samir OUNZAIN, Marco MINA, Daniel Roman BLESSING
Life of this patent
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Abstract
Disclosed herein are modulators of a long non-coding RNA (lncRNA), wherein an expression of the lncRNA is associated with idiopathic pulmonary fibrosis. Further provided herein are methods of treating idiopathic pulmonary fibrosis a subject in need thereof. Also, provided herein are methods of predicting severity and progression of idiopathic pulmonary fibrosis based on expression of the lncRNAs described herein.
Claims31
A synthetic antisense oligonucleotide of a long noncoding RNA (lncRNA), wherein the lncRNA is transcribed from a region located within a genomic locus selected from a group consisting of chr21:
- 42009177-42055325 (strand +);
- chr15:
- 38864806-39427195 (strand −);
- chr15:
- 38871616-38880364 (strand −);
- chr6:
- 169171312-169188635 (strand −);
- chr4:
- 76758554-76801964 (strand −);
- chr17:
- 50199876-50215922 (strand +);
- chr2:
- 215717811-215721161 (strand +);
- chr14:
- 74552181-74560688 (strand +);
- chr2:
- 188966458-188984794 (strand −);
- chr11:
- 1218530-1220242 (strand +);
- chr6:
- 74069451-74690727 (strand +);
- chr16:
- 86845338-87058332 (strand −);
- and chr9:
- 22646200-22824213 (strand +), relative to human genome GRCh38.p14 (GCF_000001405.40), wherein the lncRNA is a pulmonary-expressed lncRNA.
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A method of i) diagnosing idiopathic pulmonary fibrosis (IPF), or ii) monitoring, determining or predicting severity or progression of idiopathic pulmonary fibrosis (IPF) in a subject, the method comprising:
- (a) obtaining a sample from the subject;
- (b) determining an RNA expression level of one or more pulmonary expressed lncRNAs;
- and
- (c) diagnosing idiopathic pulmonary fibrosis (IPF), or monitoring, determining or predicting severity or progression of idiopathic pulmonary fibrosis (IPF) in the subject based on the measurement from step (b).
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Dependencies are inferred from the claim text.