Decoy rna oligonucleotides for inhibiting ythdf2
AssigneeCatchme Rna Therapeutics Ltd.
InventorsYael TSALENCHUCK, Vladislav KRUPALNIK, Shay GEULA, Or YAKOV
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Abstract
Nucleic acid molecule comprising a YTH domain-containing family protein 2 (YTHDF2) binding site are provided. Pharmaceutical compositions comprising the nucleic acid molecules and methods of inhibiting YTHDF2 or treating a disease with the nucleic acid molecules and compositions are also provided.
Claims57
A nucleic acid molecule comprising a YTH domain-containing family protein 2 (YTHDF2) binding site and a 5′ enhancer motif located 5′ to said binding site, wherein said 5′ enhancer motif is selected from GGGAAACU, CUGCUGCU, GGAGAGCU, UGGCCACC and AUGAGUCCAAC (SEQ ID NO:
- 44) and wherein said molecule comprises 13-100 nucleotides.
A nucleic acid molecule comprising a YTHDF2 binding site, wherein said molecule comprises 10-100 nucleotides and a phosphorothioate (PS) modified backbone.
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Dependencies are inferred from the claim text.