Antisense RNA (asRNA) Technology and Use Thereof
Assignee1Globe Health Institute LLC
InventorsChiang J. LI, Xiangao SUN, Charles LI
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Abstract
The present invention discloses a novel type of gene modulation technology for modulating target nucleic acid and/or protein levels in cells, tissues, organisms and animals. The new technology provides compositions for use in gene modulation applications, including prevention and treatment of human diseases. The composition comprises a short antisense RNA (asRNA) molecule having at least one interspersed motif of deoxyribonucleotide monomer(s). The present invention further provides methods of using the compositions for modulating expression or function of a target gene, or for treatment or prevention of diseases as well as for biomedical research, disease diagnosis and other biological applications.
Claims25
A short antisense RNA (asRNA) molecule comprising a single strand of linked nucleotide monomers,
- wherein the strand is substantially complementary to a targeted segment of a targeted RNA through at least one targeting region, and has a length selected from the group consisting of 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 and 50 nucleotide monomers;
- and
- wherein the asRNA molecule comprises at least one interspersed segment of deoxyribonucleotide monomer(s) (ISD) that each ISD, independently of each other, comprises either one deoxyribonucleotide monomer, or at least 2, 3, 4, 5, 6, 7 or 8 contiguous one deoxyribonucleotide monomer.
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Dependencies are inferred from the claim text.