Methods for the manufacture of proteolytically processed polypeptides

A composition comprising a proteolytically-processed polypeptide, the composition obtainable by a method comprising contacting a first polypeptide comprising an amino acid sequence having at least 50% sequence identity with SEQ ID NO:

• 1 with a second polypeptide that is recombinant or purified and is susceptible to proteolysis by the first polypeptide, resulting in the proteolytic processing of the second polypeptide into at least two cleavage products, thereby providing the proteolytically-processed polypeptide.