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US 2026/0286328 A1Published application
Cas13 protein, and crispr-cas system, and use thereof
AssigneeYoltech Therapeutics Co., Ltd
InventorYuxuan WU
Life of this patent
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Abstract
A Cas13 protein, a CRISPR-Cas system, and use thereof. The amino acid sequences of the Cas13 protein are as shown in SEQ ID NO. 1 to SEQ ID NO. 9, and are respectively named as Cas13a_10, Cas13a_11, Cas13b_3, Cas13b_4, Cas13b_5, Cas13T_9, Cas13T_15, Cas13T_16, and Cas13Z_2; these nine Cas13 proteins have low homology with the previously reported Cas13 proteins, and exhibit a RNA nuclease activity, showing great prospects in gene editing.
Claims30
A Cas13 protein, wherein the Cas13 protein is a protein as defined in (a) or (b) below:
- (a) a protein comprising an amino acid sequence represented by SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5, SEQ ID NO. 6, SEQ ID NO. 7, SEQ ID NO. 8, or SEQ ID NO. 9;
- (b) a protein being derived by substituting, deleting, or adding one or more amino acids in the amino acid sequence defined in (a), and substantially retaining the biological function of the sequence from which it is derived.
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Dependencies are inferred from the claim text.