Method of production of modified phage and method of treatment using same

Abstract

A method of producing modified bacteriophage (“phage”) that are capable of infecting and causing lysis of a parent host bacteria that is insensitive to the unmodified phage is disclosed. The method comprises: treating a host bacteria insensitive to a selected phage strain with a suitable amount of the said phage strain and at least one antibacterial agent comprising protein synthesis inhibitory activity, and culturing the bacteria for a period and under conditions suitable for the phage to infect the bacteria and replicate to generate progeny phage; and recovering and expanding progeny phage which are phage with a modified capability to infect and cause lysis of said host bacteria. Methods of treatment involving the use of the modified phage, as well as pharmaceutical compositions comprising same are also disclosed.

Dependencies are inferred from the claim text.