Creating biological fibers for tissue constructs

Abstract

Devices, systems, and techniques are described for creating pre-aligned cells in fibers to be wound into tissue constructs or microtissues that can be printed into larger tissue constructs. For example, a method includes dispensing a biological fiber into a solution, wherein the biological fiber comprises a plurality of cells within a hydrogel. The method may then include spooling, under tension, the biological fiber from the solution and onto a spool structure. In some examples, the method may also include winding the biological fiber around a tissue frame to create a tissue construct or cutting the biological fiber matured into a pre-aligned microtissue from the spool structure and used in a bioink for printing tissue constructs.

Dependencies are inferred from the claim text.