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AssigneesThe Asan Foundation, University of Ulsan Foundation for Industry Cooperation
InventorsHun LEE, Eun Ah YE
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The present invention relates to a composition for inducing the differentiation of stem cells into corneal endothelial cells and a method for inducing differentiation using same. By using the differentiation composition according to one aspect of the present invention, the time and cost required for differentiation from stem cells to corneal endothelial cells can be reduced, with the consequent increase of differentiation efficiency. The corneal endothelial cells differentiated by the method exhibit gene expression patterns specific to corneal endothelial cells similar to those of human-derived corneal endothelial cells and thus can be widely applied as an alternative cell source for corneal endothelial cell transplantation.
A method of differentiating stem cells into corneal endothelial cells (CECs), the method comprising culturing the stem cells in a culture medium comprising a Rho-associated protein kinase (ROCK) inhibitor to differentiate the stem cells into CECs.
A medium composition for inducing direct differentiation of stem cells into corneal endothelial cells, the composition comprising a Rho-associated protein kinase (ROCK) inhibitor.
A kit for inducing direct differentiation of stem cells into corneal endothelial cells (CECs), the kit comprising:
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