Antibody compositions
AssigneeLindy Biosciences, Inc.
InventorsDeborah Lee Bitterfield, Michael Quinn Doherty
Life of this patent
Estimating the term…
Abstract
Described herein are isolated cell culture components such as, e.g., biologics and/or lipids, and methods for isolating cell culture components from a liquid cell culture medium. Methods of the present invention may include contacting a dehydration composition and a liquid cell culture medium comprising a target component to form a mixture; forming an at least partially dehydrated component in the mixture; and separating the at least partially dehydrated component from the mixture, thereby providing an isolated component. In some embodiments, the isolated component comprises the at least partially dehydrated component. In some embodiments, the isolated component is present in a composition separated from the at least partially dehydrated component.
Claims30
A composition comprising:
- a plurality of particles, wherein each particle of the plurality of particles comprises an amorphous antibody or a fragment thereof and the amorphous antibody or a fragment thereof is present in an amount of at least 65% by weight of the plurality of particles,
- wherein the plurality of particles has a water content of less than 10% and a water activity of 0.25 or less, and
- wherein the composition comprises aggregates of the antibody or a fragment thereof in an amount less than 5% by weight of the antibody or a fragment thereof in the composition.
A composition comprising:
- a solvent and a plurality of particles,
- wherein each particle of the plurality of particles comprises an amorphous antibody or a fragment thereof and the plurality of particles has a water content of less than 10% and a water activity of less than 0.75,
- wherein the composition comprises the plurality of particles in an amount of at least 25% by weight of the composition, and
- wherein the plurality of particles are suspended in the solvent.
Dependencies are inferred from the claim text.