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AssigneeCytiva Sweden AB
InventorsTuomo Frigård, Camilla Estmer Nilsson, Patricia Roch, Björn Markus Olovsson, Magnus Wetterhall, Nils Stafström, Inger Salomonsson
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The present invention relates to a computer implemented method for controlling a fluid coupling network (170), the fluid coupling network (170) being configured to be fluidly couplable to bioreactor (110), a gas source (120), a buffer source (140), a waste port (150), a processing system (160) and a conduit reservoir (208), the fluid coupling network (170) comprising a barrier unit (220) configured to sterilely separate fluid paths within the fluid coupling network (170), the fluid coupling network (170) being controllable to sample the bioreactor (110), the method comprising obtaining (510) a fluid sample from the bioreactor (110), wherein the step of obtaining the fluid sample comprises controlling a flow of fluid from the bioreactor (110) via the conduit reservoir (208) and the fluid coupling network (170) to the waste port (150), to fill the conduit reservoir (208) with the fluid from the bioreactor (110), providing (530) the fluid sample, wherein the step of providing the fluid sample comprises to provide the fluid sample to the processing system (160) from the conduit reservoir (208) via the fluid coupling network (170), and returning (540) residual fluid sample to the bioreactor (110), wherein the residual fluid sample is comprised by a part of the fluid coupling network (170) separated by the barrier unit (220), wherein the step of returning residual fluid sample comprises controlling a flow of gas from a gas source (120) to the bioreactor (110) via the part of the fluid coupling network (170).
A sampling module comprising a conduit reservoir fluidly arranged between a bioreactor interface and a processing interface, wherein the bioreactor interface is configured for direct or indirect fluid connection with a bioreactor, wherein the processing interface is configured for selective fluid connection with either a fluid sample processing system or a waste port, the sampling module comprising a second and third controllable valve, the conduit reservoir being fluidly connected to the bioreactor interface via the second controllable valve, and fluidly connected to the processing interface via the third controllable valve, wherein the conduit reservoir defines an internal volume configured to temporarily contain a fluid sample, and wherein operation of the second and third controllable valves defines at least two distinct configuration of the sampling module comprising:
Dependencies are inferred from the claim text.