Microfluidic devices and methods of designing and using microfluidic devices

A method, comprising:

• receiving measurement data representing an interaction between a molecular compound and each organ construct of a plurality of organ constructs, each organ construct of the plurality of organ constructs corresponding to an organ type of a plurality of organ types;
• generating, based on the measurement data, a plurality of concentration profiles, each concentration profile of the plurality of concentration profiles corresponding to an organ construct of the plurality of organ constructs;
• generating, for each organ type of the plurality of organ types and based on the concentration profiles, at least one pharmacokinetic (PK) parameter value;
• translating, based on the type of at least one of the organ constructs, the at least one PK parameter value into a second PK parameter value, the translating comprising executing a quantitative systems pharmacology (QSP) model that includes an empirical scaling factor (ESF) to scale in vitro parameters to in vivo parameters;
• determining, based on the second PK parameter, at least one physical parameter value for one or more organ constructs of a multi-organ construct platform;
• and
• forming the multi-organ construct platform with the one or more organ constructs in accordance with the physical parameter value.

A system comprising:

• at least one inlet;
• a plurality of organ constructs, each organ construct of the plurality of organ constructs being sized relative to other organ constructs of the plurality of organ constructs based on at least one predetermined human pharmacokinetic (PK) parameter;
• and
• a plurality of channels, each channel of the plurality of channels causing an organ construct of the plurality of organ constructs to be in fluidic communication for recirculating fluid media with at least one other organ construct of the plurality of organ constructs.