Ophthalmic lens comprising an acrylonitrile compound

An ophthalmic lens comprising:

• a plastic base, and
• a compound of Formula (I) or a salt thereof, in particular a hydrochloride salt or a sulfate salt
• wherein:
• R1 is chosen from —CN, —CONH2, —CO2R6 or —SO2—(C1-C12)alkyl, R2 is, independently from R3, R4 and R5, chosen from H, F, Cl, Br, I, —OH, —OR7, —SH, —SR8, —SOR9, SO2R10, —NH2, —NHR11, —N(R12)2, —NHCOR13, —NHSO2OR14, —NO2, —CN, (C1-C12)alkyl, (C1-C12)haloalkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, (C1-C12)heteroalkyl, (C3-C12)cycloalkyl, (C3-C12)heterocycloalkyl, (C6-C18)aryl, (C6-C18)aryl-(C1-C12)alkyl, (5 to 10 membered)heteroaryl or (5 to 10 membered)heteroaryl-(C1-C12)alkyl, R3, R4 and R5 are independently chosen from H, F, Cl, Br, I, —OH, —OR7, —SH, —SR8, —SOR9, SO2R10, —NH2, —NHR11, —N(R12)2, —NHCOR13, —NHSO2OR14, —NO2, —CN, (C1-C12)alkyl, (C1-C12)haloalkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, (C1-C12)heteroalkyl, (C3-C12)cycloalkyl, (C3-C12)heterocycloalkyl, (C6-C18)aryl, (C6-C18)aryl-(C1-C12)alkyl, (5 to 10 membered)heteroaryl or (5 to 10 membered)heteroaryl-(C1-C12)alkyl,
• X is NH, NR15, O, or S,
• R6, R7, R8, R9, R10, R11 R12, R13 and R14 are independently chosen from (C1-C12)alkyl, (C1-C12)haloalkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, (C1-C12)heteroalkyl, (C3-C12)cycloalkyl, (C3-C12)heterocycloalkyl, (C6-C18)aryl, (C6-C18)aryl-(C1-C12)alkyl, (5 to 10 membered)heteroaryl or (5 to 10 membered)-heteroaryl-(C1-C12)alkyl,
• R15 is chosen from (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, (C1-C12)heteroalkyl, (C3-C12)cycloalkyl, (C3-C12)heterocycloalkyl, (C6-C18)aryl, (C6-C18)aryl-(C1-C12)alkyl, (5 to 10 membered)heteroaryl, (5 to 10 membered)heteroaryl-(C1-C12)alkyl, said alkyl being optionally substituted by one to three R16 groups,
• R16 is chosen from halogen atoms, (C1-C12)alkoxy, (C6-C18)aryl,
• or wherein R15 is a structure of Formula a:
• in which
• L is (C1-C12)alkylene,
• R1a is chosen from —CN, —CONH2, —CO2R6a or —SO2—(C1-C12)alkyl,
• R2a is, independently from R3a, R4a and R5a, chosen from H, F, Cl, Br, I, —OH, —OR7a, —SH, —SR8a, —SOR9a, SO2R10a, —NH2, —NHR11a, —N(R12a)2, —NHCOR13a, —NHSO2OR14a, —NO2, —CN, (C1-C12)alkyl, (C1-C12)haloalkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, (C1-C12)heteroalkyl, (C3-C12)cycloalkyl, (C3-C12)heterocycloalkyl, (C6-C18)aryl, (C6-C18)aryl-(C1-C12)alkyl, (5 to 10 membered)heteroaryl or (5 to 10 membered)heteroaryl-(C1-C12)alkyl,
• R3a, R4a and R5a are independently chosen from H, F, Cl, Br, I, —OH, —OR7, —SH, —SR5a, —SOR9a, SO2R10a, —NH2, —NHR11a, —N(R12a)2, —NHCOR13a, —NHSO2OR14a, —NO2, —CN, (C1-C12)alkyl, (C1-C12)haloalkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, (C1-C12)heteroalkyl, (C3-C12)cycloalkyl, (C3-C12)heterocycloalkyl, (C6-C18)aryl, (C6-C18)aryl-(C1-C12)alkyl, (5 to 10 membered)heteroaryl or (5 to 10 membered)heteroaryl-(C1-C12)alkyl,
• R6a, R7a, R5a, R9a, R10a, R11a, R12a, R13a and R14a are independently chosen from (C1-C12)alkyl, (C1-C12)haloalkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, (C1-C12)heteroalkyl, (C3-C12)cycloalkyl, (C3-C12)heterocycloalkyl, (C6-C18)aryl, (C6-C18)aryl-(C1-C12)alkyl, (5 to 10 membered)heteroaryl or (5 to 10 membered)-heteroaryl-(C1-C12)alkyl,
• wherein the aryl or heteroaryl groups are optionally substituted by one or more substituents, in particular by 1 or 2 substituents, said substituents being in particular chosen from:
• halogen, in particular F or Cl,
• carboxylic ester, in particular methyl ester or ethyl ester,
• (C1-C12)alkyl, in particular methyl, ethyl or iso-propyl,
• (C1-C12)alkoxy, in particular methoxy or ethoxy,
• carboxylic acid,
• nitrile,
• amine, in particular —NH2, NHCH3, or N(CH3)2.