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US 2026/0286003 A1Published application
Antibodies and assays for detection of folate receptor 1
AssigneeImmunoGen, Inc.
InventorsOlga AB, Daniel TAVARES, Julianto SETIADY, Sharron LADD, Christina N. CARRIGAN, Lingyun RUI
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Abstract
The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.
Claims25
1-3. (canceled)
An antibody or antigen-binding fragment thereof that specifically binds to an epitope of FOLR1 comprising an N-glycoslated amino acid, wherein said antibody or fragment thereof competitively inhibits binding to FOLR1 of an antibody selected from the group consisting of:
- (a) an antibody comprising the polypeptide of SEQ ID NO:27 and the polypeptide of SEQ ID NO:28;
- (b) an antibody comprising the polypeptide of SEQ ID NO:29 and the polypeptide of SEQ ID NO:30;
- (c) an antibody comprising the polypeptide of SEQ ID NO:31 and the polypeptide of SEQ ID NO:32;
- (d) an antibody comprising the polypeptide of SEQ ID NO:62 and the polypeptide of SEQ ID NO:63 or SEQ ID NO:64;
- and
- (e) an antibody comprising the polypeptide of SEQ ID NO:65 and the polypeptide of SEQ ID NO:66 or SEQ ID NO:67.
3 more elements
8-21. (canceled)
(canceled)
26-30. (canceled)
34-89. (canceled)
Dependencies are inferred from the claim text.