Novel anti-gprc5d antibody

An anti-GPRC5D antibody or an antigen binding fragment thereof, comprising three heavy chain complementarity determining regions HCDR1, HCDR2 and HCDR3, and three light chain complementarity determining regions LCDR1, LCDR2 and LCDR3, wherein

• a) the HCDR1 comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
• 4 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, or SEQ ID NO:
• 9 or a variant thereof having no more than 3, 2 or 1 amino acid substitution;
• b) the HCDR2 comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
• 5 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, or SEQ ID NO:
• 10 or a variant thereof having no more than 3, 2 or 1 amino acid substitution;
• c) the HCDR3 comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
• 6 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, or SEQ ID NO:
• 11 or a variant thereof having no more than 3, 2 or 1 amino acid substitution;
• d) the LCDR1 comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
• 1 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, or SEQ ID NO:
• 7 or a variant thereof having no more than 3, 2 or 1 amino acid substitution;
• e) the LCDR2 comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
• 2 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, or SEQ ID NO:
• 8 or a variant thereof having no more than 3, 2 or 1 amino acid substitution;
• and
• f) the LCDR3 comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
• 3 or a variant thereof having no more than 3, 2 or 1 amino acid substitution;
• or wherein
• a) the HCDR1 comprises the amino acid sequence as shown in SEQ ID NO:
• 4 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, the HCDR2 comprises the amino acid sequence as shown in SEQ ID NO:
• 5 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, the HCDR3 comprises the amino acid sequence as shown in SEQ ID NO:
• 6 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, the LCDR1 comprises the amino acid sequence as shown in SEQ ID NO:
• 1 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, the LCDR2 comprises the amino acid sequence as shown in SEQ ID NO:
• 2 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, and the LCDR3 comprises the amino acid sequence as shown in SEQ ID NO:
• 3 or a variant thereof having no more than 3, 2 or 1 amino acid substitution;
• or
• b) the HCDR1 comprises the amino acid sequence as shown in SEQ ID NO:
• 9 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, the HCDR2 comprises the amino acid sequence as shown in SEQ ID NO:
• 10 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, the HCDR3 comprises the amino acid sequence as shown in SEQ ID NO:
• 11 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, the LCDR1 comprises the amino acid sequence as shown in SEQ ID NO:
• 7 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, the LCDR2 comprises the amino acid sequence as shown in SEQ ID NO:
• 8 or a variant thereof having no more than 3, 2 or 1 amino acid substitution, and the LCDR3 comprises the amino acid sequence as shown in SEQ ID NO:
• 3 or a variant thereof having no more than 3, 2 or 1 amino acid substitution.