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US 2026/0285953 A1Published application
Red Light-Controlled Protein Dimerization Systems
AssigneeUniversity of Washington
InventorsLiangcai GU, Zhimin HUANG, Xiao ZHANG
Life of this patent
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Abstract
Deinococcus radiodurans phytochrome (DrBphP) light form-binding antibodies are disclosed and their use in light-induced dimerization systems.
Claims15
A kit, comprising ore or more of:
- (I) a Deinococcus radiodurans bacteriophytochrome (DrBphP) light form-binding single chain antibody, wherein single chain antibody comprises a set of complementarity-determining regions (CDRs) selected from the group consisting of:
- (a) SEQ ID NO:1 (CDR1), SEQ ID NO:2 (CDR2), and SEQ ID NO:3 (CDR3);
- or
- (b) SEQ ID NO:4 (CDR1), SEQ ID NO:5 (CDR2), and SEQ ID NO:6 (CDR3);
- or
- (II) a nucleic acid encoding a Deinococcus radiodurans bacteriophytochrome (DrBphP) light form-binding single chain antibody, wherein single chain antibody comprises a set of complementarity-determining regions (CDRs) selected from the group consisting of:
- (a) SEQ ID NO:1 (CDR1), SEQ ID NO:2 (CDR2), and SEQ ID NO:3 (CDR3);
- or
- (b) SEQ ID NO:4 (CDR1), SEQ ID NO:5 (CDR2), and SEQ ID NO:6 (CDR3);
- or
- (III) an expression vector comprising a nucleic acid encoding a Deinococcus radiodurans bacteriophytochrome (DrBphP) light form-binding single chain antibody, wherein single chain antibody comprises a set of complementarity-determining regions (CDRs) selected from the group consisting of:
- (a) SEQ ID NO:1 (CDR1), SEQ ID NO:2 (CDR2), and SEQ ID NO:3 (CDR3);
- or
- (b) SEQ ID NO:4 (CDR1), SEQ ID NO:5 (CDR2), and SEQ ID NO:6 (CDR3);
- or
- (IV) a cell that comprising an expression vector, wherein the expression vector comprises a nucleic acid encoding a Deinococcus radiodurans bacteriophytochrome (DrBphP) light form-binding single chain antibody, wherein single chain antibody comprises a set of complementarity-determining regions (CDRs) selected from the group consisting of:
- (a) SEQ ID NO:1 (CDR1), SEQ ID NO:2 (CDR2), and SEQ ID NO:3 (CDR3);
- or
- (b) SEQ ID NO:4 (CDR1), SEQ ID NO:5 (CDR2), and SEQ ID NO:6 (CDR3).
16 more elements
Dependencies are inferred from the claim text.