Double site-directed antibody-functional molecular conjugate, and preparation method therefor and use thereof

Abstract

A double site-directed antibody-functional molecular conjugate, and a preparation method therefor and the use thereof. The double site-directed antibody-functional molecular conjugate comprises an antibody, linking fragments 1 and 2 and a functional molecule, wherein the functional molecule is coupled to a conserved glycosylation site in the Fc region of the antibody by the linking fragment 1 and is coupled to a lysine site at position 246 or 248 of the antibody by the linking fragment 2. The double site-directed antibody-functional molecular conjugate has good stability, cytotoxicity and in-vivo activity, has good druggability, etc., and can be used in the preparation of a drug, diagnostic and therapeutic reagents and a kit for treating tumors, diseases caused by inflammation, diseases caused by a virus infection and immune diseases. The preparation method has the advantages of simple operation, few purification steps, etc., and has a good druggability and is easy to industrialize.

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