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US 2026/0285943 A1Published application
Polymerized hemoglobins and related compounds and methods
AssigneeThe Regents of the University of California
InventorsPedro Cabrales, Carlos Munoz, Daniela Lucas
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Abstract
The present disclosure is related to a solution comprising hemoglobins including polymerized hemoglobins (TgHbs). In some embodiments, a method can comprise adding a transglutaminase to a solution including hemoglobins, to polymerize at least some of the hemoglobins to form polymerized hemoglobins.
Claims35
A method comprising:
- introducing a transglutaminase to a solution that contains a plurality of hemoglobins to polymerize at least a portion of the plurality of the hemoglobins to form polymerized hemoglobins.
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A composition comprising:
- a plurality of hemoglobins, wherein at least a portion of the plurality of hemoglobins comprises polymerized hemoglobins;
- and
- an amount of transglutaminase.
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An aqueous solution comprising:
- a plurality of hemoglobins, wherein at least a portion of the plurality of hemoglobins comprises transglutaminase-polymerized hemoglobins (TgHbs), and
- wherein a viscosity of the aqueous solution at a shear rate of about 100 s−1 at about 37° C. changes by about 25 cP or more when an oxygenation state of the TgHbs changes from about a deoxygenated state to about a fully oxygenated state.
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Dependencies are inferred from the claim text.