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US 2026/0285932 A1Published application
Peptide tyrosine-tyrosine analog and use thereof
AssigneeThe United Bio-Technology (Hengqin) Co., Ltd.
InventorsLiang HUANG, Xiaoxiao LIU, Chunlai CAO, Cui ZHOU, Xiuyi HE, Huixing DENG, Xin XIE
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Abstract
The present application relates to the pharmaceutical field, and specifically provides a novel peptide tyrosine-tyrosine (PYY3-36) analogue or its salt or solvate, having a sequence structure of the following general formula (I): The novel peptide YY analogue (PYY3-36) provided by the present application has better pharmacological effects, longer action time, excellent bioavailability and safety.
Claims14
A peptide tyrosine-tyrosine (PYY3-36) analogue or its salt or solvate, comprising a sequence structure of the following general formula (I):
- wherein ψ is Lys whose side chain is modified with the structure of the following general formula (II):
- Y-Z (II), wherein Y is (AEEAc or Glu)a-(AEEAc or Glu)b-(AEEAc or Glu)c, wherein a, b, and c are each independently 0 or 1, and a, b, and c are not all 0 at the same time, the carboxyl end of Y is connected to the ε-amino group of the side chain of Lys, Z is —CO—(CH2)m—COOH, and m is an integer between 6-24,
- X10 is E or Aib;
- X12 is A or Aib;
- X22 is A or Aib;
- X23 is S or E;
- R1 is NH2 or OH;
- and at least one of X10, X12, and X22 is Aib.
5 more elements
Dependencies are inferred from the claim text.