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US 2026/0285915 A1Published application
Glycosylated yghj polypeptides from uropathogenic e. coli
AssigneeGlyprovac Aps
InventorsAnders BOYSEN, Mette THORSING, Ann ZAHLE ANDERSEN
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Abstract
The present invention relates to YGHJ polypeptides with novel glycosylation patterns. The glycosylated polypeptides are expressed in an avirulent genetically altered strain of the natural pathogenic bacteria, which gives rise to glycosylated YGHJ polypeptides which resembles the wildtype polypeptide to a higher degree than polypeptides expressed in E. coli production strains. The invention also relates to uses of such polypeptides and production strains.
Claims20
A genetically modified E. coli which:
- does not express FimH;
- does not express PapG;
- and
- does not express WaaL.
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Dependencies are inferred from the claim text.