Masking polypeptides, activatable cytokine constructs, and related compositions and methods

Abstract

Provided herein are activatable cytokine constructs that include a novel masking moiety, a cytokine polypeptide, and a cleavable moiety between the masking moiety and the cytokine polypeptide. In some embodiments, the ACC is a monomer. In some embodiments, the ACC is a complex of two, three, four, or more constructs. In some embodiments, the ACC is a dimer complex comprising a first monomer construct comprising a first cytokine polypeptide, a first masking moiety, and a first dimerization domain, and a second monomer construct comprising a second cytokine polypeptide and/or an agonist of the first cytokine polypeptide and a second dimerization domain, and optionally a second masking moiety, wherein the first and/or second masking moiety is the novel masking moiety.

Dependencies are inferred from the claim text.