Synthesized biologically active compounds and methods of making and using

A compound having the structure:

• wherein:
• (i) is a single or double bond;
• (ii) A1 is an amino acid residue wherein the amino acid forming A1 has a pH similar to glutamic acid;
• (iii) A2 is an amino acid residue wherein the amino acid forming A2 has a pH similar to glycine;
• (iv) R1 is an oxygen, a hydroxyl, or —OR6, and R6 is an unsubstituted linear, branched, or cyclol C1-C6 alkyl;
• (v) R′1 is a hydrogen, a hydroxyl, or —OR8, and R8 is an unsubstituted linear, branched, or cyclol C1-C6 alkyl;
• (vi) R2-R5 are independently a hydrogen, a hydroxyl, a halogen, an haloalkyl (e.g., —CF3), or —OR7, R7 is an unsubstituted linear, branched, or cyclol C1-C6 alkyl, —C(═O)R9, R9 is hydrogen, an unsubstituted linear, branched, or cyclol C1-C6 alkyl, or —OR10, and R10 is hydrogen or an unsubstituted linear, branched, or cyclol C1-C6 alkyl;
• (vii) L1 is a single bond or —(CH2)m—, m is an integer from 1 to 8;
• (viii) R11 is a hydrogen, an unsubstituted or substituted linear C1-C10 alkyl, an unsubstituted or substituted branched C3-C10 alkyl, an unsubstituted or substituted C3-C10 cycloalkyl, or an unsubstituted or substituted C5-C12 aryl;
• and
• (ix) each substituent, when present, is independently a halogen, a hydroxyl, an haloalkyl, an unsubstituted linear, branched, or cyclol C1-C6 alkyl, an unsubstituted C5-C12 aryl, or —OR12, R12 is an unsubstituted linear, branched, or cyclol C1-C6 alkyl, and wherein the compound is not: