US 2026/0285897 A1 · Neurosteroids and Prodrugs Thereof

Abstract

Disclosed are neurosteroids and prodrugs thereof. Pharmaceutical formulations containing the neurosteroids and prodrugs are also disclosed. Additionally, methods of treating a condition, disorder, or disease using the neurosteroids, prodrugs, or pharmaceutical formulations are disclosed. Exemplary conditions, disorders, and diseases relevant to this disclosure include stroke, subarachnoid hemorrhage, cerebral ischemia, cerebral vasospasm, hypoxia, CNS injury, concussion, traumatic brain injury, depression, postpartum depression, epilepsy, seizure disorder, essential tremor, fragile X syndrome, and neurodegenerative disease.

Claims21

Dependent claims

A compound having a structure of Formula I or a pharmaceutically acceptable salt, hydrate, or hydrated salt thereof:

wherein RG is hydrogen or methyl;
wherein RH is hydrogen or an optionally substituted nitrogen-containing 5-membered heteroaryl;
wherein Zt is —ORX, wherein RX is selected from hydrogen, acyl, ester, thioester, and amide;
and
wherein Z2 is methyl, halogen-substituted methyl, methoxymethyl, or halogen-substituted methoxymethyl.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

19/168,284Filed 25 Mar 2024

Priority

23 Mar 2023

Published

24 Sep 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07J 7/002
Not substituted in position 17 alfa: not substituted in position 16
A61K 31/57
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids: substituted in position 17 beta by a chain…
A61K 31/58
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids: containing heterocyclic rings, e.g. danazol,…
A61P 25/00
Drugs for disorders of the nervous system

Neurosteroids and Prodrugs Thereof

Life of this patent

Neurosteroids and Prodrugs Thereof

Life of this patent

Abstract

Claims21