Small molecule glp-1 agonists
AssigneeAmbrosia Biosciences Inc.
InventorsDonald Backos, Bismarck Campos, Natalie Dwulet, Erik James Hicken, Michael Hilton, Dean Kahn, Robert Pipal
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds of formulae (I) and (I-a), and pharmaceutically acceptable salts thereof, which are useful as GLP-1R agonists. Also provided are pharmaceutical compositions comprising a compound of formula (I) or (I-a), or a pharmaceutically acceptable salt thereof, and methods involving use of the compounds or pharmaceutically acceptable salts thereof and compositions in the treatment of various GLP-1-associated diseases, disorders, and conditions, such as obesity.
Claims51
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof;
- wherein,
- A is optionally substituted arylene, heteroarylene, or heterocycloalkylene;
- B is -(alkylene)O(alkylene)-, alkylene, haloalkylene, alkenylene, —O(alkylene)-, -(alkylene)O—, —O(alkylene)O—, —O(alkylene)O(alkylene)-, -(alkylene)O(alkylene)O—, —S(alkylene)-, -(alkylene)S—, -(alkylene)S(alkylene)-, —S(alkylene)S—, —S(alkylene)S(alkylene)-, -(alkylene)S(alkylene)S—, —NH(alkylene)-, -(alkylene)NH—, -(alkylene)NH(alkylene)-, —NH(alkylene)NH—, —NH(alkylene)NH(alkylene)-, -(alkylene)NH(alkylene)NH—, —N(alkyl)(alkylene)-, -(alkylene)N(alkyl)-, or is a bond;
- C is optionally substituted arylene, heteroarylene, or heterocycloalkylene;
- Ring D is
- Ring Z is heterocycloalkylene or heteroarylene;
- R1 is independently for each occurrence alkyl, alkoxy, or halo;
- or two geminal occurrences of R1 taken together with the carbon atom to which they are attached form an optionally substituted spirocyclic cycloalkyl ring;
- R2 is independently for each occurrence alkyl, alkoxy, or halo;
- R3 is haloalkyl, unsubstituted cycloalkyl, cycloalkyl substituted with alkyl, cycloalkyl substituted with haloalkyl, cycloalkyl substituted with halo, unsubstituted heteroaryl, heteroaryl substituted with alkyl, heteroaryl substituted with halo, unsubstituted heterocycloalkyl, heterocycloalkyl substituted with alkyl, heterocycloalkyl substituted with halo, haloalkoxy, —NH2, —NH(alkyl), or —N(alkyl)2;
- R3a is independently for each occurrence alkyl, alkoxy, halo, haloalkyl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, haloalkoxy, —NH2, —NH(alkyl), or —N(alkyl)2;
- R4 is independently for each occurrence alkyl, alkoxy, or halo;
- k is an integer selected from 0-2;
- m is an integer selected from 0-6;
- n is an integer selected from 0-4;
- p is an integer selected from 0-4;
- and
- q is an integer selected from 0-2.
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A compound, wherein the compound is selected from:
- or a pharmaceutically acceptable salt thereof.
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Dependencies are inferred from the claim text.