Compounds, compositions and methods thereof

A compound has the structure of formula I:

• or a salt thereof, wherein:
• R1 is an isostere of —C(O)OH, or —C(O)OR11, —C(O)N(R12)SO2R13, —C(O)NR14R15, or
• —X1═X2— is —X1═X2— and X1 and X2 is independently —N═, —CR2═, or optionally substituted —CH═;
• or —X1 ═X2— is optionally substituted (CH2)2—;
• R2 is optionally substituted C1-6 alkyl;
• X3 is —N═, or —CR3═;
• X4 is —N═, or —CR4═;
• each of R3, R4 and R5 is independently R′, OR′, halogen, —CN, —NO2, or —N(R′)2;
• each of R11, R12, R13, R14 and R15 is independently R′;
• L is optionally substituted —(CH2)m—;
• m is 1 or 2;
• Ring A is an optionally substituted ring selected from a 6-10 membered aryl ring and a 5-10 membered heteroaryl ring having 1-6 heteroatoms, or Ring A is
• wherein each Ra is independently —R′, —OR′, halogen, —CN, —NO2, or —N(R′)2 and n is 1-5;
• each R′ is independently R, —OR, —C(O)R, —C(O)OR, or —S(O)2R;
• each R is independently hydrogen or an optionally substituted group selected from C1-C6 aliphatic, C1-C6 heteroaliphatic having 1-3 heteroatoms, 3-10 membered cycloaliphatic, 3-10 membered heterocyclyl having 1-4 heteroatoms, 6-10 membered aryl, 5-10 membered heteroaryl having 1-6 heteroatoms, 6-10 membered aryl-C1-C6 aliphatic, and 5-10 membered heteroaryl having 1-6 heteroatoms-C1-C6 aliphatic;
• or
• two R groups on the same atom are optionally and independently taken together with the atom to form an optionally substituted 3-10 membered ring having, in addition to the atom, 0-4 heteroatoms;
• or
• two R groups on two atoms are optionally and independently taken together with their intervening atoms to form an optionally substituted 3-10 membered ring having, in addition to the intervening atoms, 0-4 heteroatoms.