Inhibitor of complement factor b

A compound represented by General Formula (I) or an isomer or a pharmaceutically acceptable salt thereof:

• wherein:
• X is selected from CH2, NH, S, O or
• Y and Z are each independently selected from CH or N;
• and when X is CH2, Z is N;
• R1 is selected from C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl or C3-C6 heterocyclic group, the C1-C6 alkyl or C3-C6 cycloalkyl is optionally substituted with halogen, oxo group, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 heterocyclic group or C3-C6 halocycloalkyl;
• R2 is hydrogen, or R1 and R2 together with the atoms to which they are attached, form a C10-15 heterocyclic group, the heterocyclic group is optionally substituted with halogen;
• R3 is selected from C1-C6 alkyl or C3-C6 cycloalkyl, the C1-C6 alkyl is optionally substituted with deuterium or halogen.