Substituted pyridine derivatives as sarm1 inhibitors

A compound of Formula (I′):

• or a pharmaceutically acceptable salt thereof, wherein:
• Z is selected from O or N(R6);
• X is a bond or —C(R7)(R8)—;
• R1 is H or C1-6alkyl;
• R2 is H or C1-6alkyl;
• R3 is selected from H, halogen, C1-6alkyl, and C1-6haloalkyl;
• R4 is selected from C3-6cycloalkyl and C2-9heterocycloalkyl, wherein C3-6cycloalkyl and C2-9heterocycloalkyl are substituted with 1, 2, 3, 4, or 5 groups independently selected from halogen, —CN, C1-6haloalkyl, and C1-4haloalkoxy, and wherein C3-6cycloalkyl and C2-9heterocycloalkyl are optionally substituted with 1, 2, 3, 4, or 5 groups independently selected from —OH, —NH2, —N(H)(C1-4alkyl), —N(C1-4alkyl)2, C1-4alkyl, and C1-4alkoxy;
• each R5 is independently selected from halogen, C1-6alkyl, and C1-6haloalkyl;
• R6 is selected from H and C1-6alkyl;
• R7 and R8 are each independently selected from H, —OR9, C1-4alkyl, and C1-4haloalkyl;
• each R9 is independently selected from H, C1-6alkyl, and C1-6haloalkyl, wherein said C1-6alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from —OH, —CN, —NH2, —N(H)(C1-4alkyl), —N(C1-4alkyl)2, halogen, C1-4alkyl, C1-4alkoxy, C1-4haloalkyl, and C1-4haloalkoxy;
• and
• n is 0, 1, 2, 3, or 4.