Quinolineimine antidegradant compounds and uses thereof

A compound having Formula (I):

• or a salt, solvate, or stereoisomer thereof, wherein:
• is a single or a double bond;
• R1 is selected from the group consisting of optionally substituted C1-C12 alkyl, —CHR1aR1b, C3-C6 cycloalkyl, 4- to 6-membered heterocyclyl, optionally substituted phenyl, and optionally substituted 5- or 6-membered heteroaryl;
• R1a is selected from the group consisting of optionally substituted phenyl, C3-C6 cycloalkyl, and optionally substituted 5- or 6-membered heteroaryl;
• R1b is selected from the group consisting of hydrogen and C1-C9 alkyl;
• R2a, R2b, and R2c are independently selected from the group consisting of hydrogen, halogen, C1-C9 alkyl, C1-C9 haloalkyl, C3-C8 cycloalkyl, C1-C8 alkoxy, C1-C8 alkylthio, C(═O)OR4, —OC(═O)R4, —C(═O)NR4R5, —NR4C(═O)R5, —NHR4, —NR4R5, —OH, —SH, —SC(═O)R4, —SC(═O)SR4, —SC(═O)NHR4, —SC(═O)NR4R5, —NHC(═O)SR4, —NR4C(═O)SR5, —NHC(═S)SR4, —NR4C(═S)SR5, 4- to 6-membered heterocyclyl, optionally substituted phenyl, optionally substituted 5- or 6-membered heteroaryl, aryloxy, arylthio, and arylamino;
• or
• R2a and R2c taken together with the two carbon atoms to which they are attached form an optionally substituted C3-C6 cycloalkyl, an optionally substituted 4- to 6-membered heterocyclyl, an optionally substituted 4- to 6-membered aryl, or an optionally substituted 4- to 6-membered heteroaryl;
• and
• R2b is selected from the group consisting of hydrogen, halogen, C1-C9 alkyl, C1-C9 haloalkyl, optionally substituted C3-C8 cycloalkyl, —OH, C1-C8 alkoxy, —SH, C1-C8 alkylthio, —C(═O)OR4, —OC(═O)R4, —C(═O)NR4R5, —NR4C(═O)R5, —NHR4, —NR4R5, —SC(═O)R4, —SC(═O)SR4, —SC(═O)NHR4, —SC(═O)NR4R5, —NHC(═O)SR4, —NR4C(═O)SR5, —NHC(═S)SR4, —NR4C(═S)SR5, optionally substituted 4- to 6-membered heterocyclyl, optionally substituted phenyl, optionally substituted 5- or 6-membered heteroaryl, aryloxy, arylthio, and arylamino;
• R3a is selected from the group consisting of hydrogen, halogen, C1-C9 alkyl, optionally substituted phenyl, —C(═O)OR4, —C(═O)NR4R5, —C(═O)SR4, —CH2OR4, —CH2OC(═O)R4, and
• and
• R3b is selected from the group consisting of hydrogen, halogen, C1-C9 alkyl, and optionally substituted phenyl;
• or
• R3a and R3b taken together with the carbon atom to which they are attached form a C3-C12 cycloalkyl;
• R3c is selected from the group consisting of hydrogen, halogen, C1-C9 alkyl, optionally substituted phenyl, —C(═O)OR4, —C(═O)NR4R5, —C(═O)SR4, —CH2OR4, —CH2OC(═O)R4, and
• and
• R3d is selected from the group consisting of hydrogen, halogen, C1-C9 alkyl, and optionally substituted phenyl;
• or
• R3c and R3d taken together with the two carbon atoms to which they are attached form a C3-C12 cycloalkyl;
• R4 at each occurrence is independently selected from the group consisting of hydrogen and C1-C9 alkyl;
• and
• R5 at each occurrence is independently selected from the group consisting of hydrogen and C1-C9 alkyl;
• R6a, R6b, R6c, and R6d at each occurrence are independently selected from the group consisting of hydrogen, C1-C12 alkyl, and optionally substituted phenyl;
• Z at each occurrence is independently selected from the group consisting of —O—, —S—, and —NR7—;
• and
• R7 at each occurrence is independently selected from the group consisting of hydrogen and C1-C6 alkyl,
• with the proviso that the compound of Formula (I) is not: