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US 2026/0285807 A1Published application
Methods of treating cancer
AssigneeInstitute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center
InventorsAlfonso Bellacosa, John Karanicolas, Timothy J. Yen, Michael Cory, Chris Parry, Rahul Prasad
Life of this patent
Estimating the term…
Abstract
Phenylsulfonamido compounds that inhibit genome-wide hypomethylation and can be used to treat cancer, including melanoma, prostate cancer, pancreatic cancer, breast cancer, colon cancer, lung cancer, ovarian cancer, and glioblastoma, are provided.
Claims28
A compound having Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- X is:
- each of R1, R2 R3, R4, and R5 is, independently, selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkoxy, substituted or unsubstituted amine, substituted or unsubstituted alkylamino, substituted or unsubstituted aminoalkoxy, and substituted or unsubstituted alkylthiol, provided that at least one of R1, R2 R3, R4, and R5 is unsubstituted C1-3alkoxy;
- R6 is selected from the group consisting of halogen, hydroxyl, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted amine, substituted or unsubstituted alkylamino, and substituted or unsubstituted aminoalkoxy;
- each of R7, R8, R9, and R12 is, independently, selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, and substituted or unsubstituted amine;
- and
- R10 and R11 are, independently, selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted cycloalkyl, or together with the nitrogen to which they are bonded form a substituted or unsubstituted heteroaryl or a substituted or unsubstituted heterocycloalkyl.
4 more elements
2-3. (canceled)
(canceled)
19-20. (canceled)
22-25. (canceled)
27-30. (canceled)
32-53. (canceled)
55-56. (canceled)
58-112. (canceled)
Dependencies are inferred from the claim text.