Ion substituted calcium phosphate particles
AssigneePsilox AB
InventorsWei XIA, Camilla BERG, Erik UNOSSON
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Abstract
The present invention relates to hollow calcium phosphate particles comprising a respective shell comprising calcium, phosphate, water, magnesium, and strontium. The particles have a mean diameter ranging from 400 nm to 1.5 μm. The invention also relates to methods of producing such particles and compositions comprising such particles.
Claims11
A method of manufacturing hollow calcium phosphate particles having a mean diameter ranging from 400 nm to 1.5 μm, wherein the hollow calcium phosphate particles comprise a respective shell comprising calcium, phosphate, water, magnesium, and strontium, wherein:
- a Ca:P atomic ratio is 0.9-1.3;
- a Sr2+ content is 1-6 wt %;
- a Mg2+ content is 5-10 wt %;
- and
- a Ca2+ content is 15-25 wt %,
- wherein the method comprises:
- forming a first salt solution comprising 0.5-1.5 mM calcium, 0.2-1.0 mM strontium, and 0.2-1.0 mM magnesium, and a second salt solution comprising 5.0-15 mM phosphate;
- mixing the first and the second salt solutions to form a mixed solution at 15-25° C.;
- heating the mixed solution to equal to or above 70° C. at a rate of 1-20° C./min forming a heated solution;
- and
- precipitating particles from the heated solution at 70-100° C. for a duration of 1 min to 24 h.
A method of treating or preventing caries and/or dentin hypersensitivity and/or enamel demineralization or decalcification defects in a subject, the method comprises administering hollow calcium phosphate particles to a surface of at least one tooth of the subject, wherein the hollow calcium phosphate particles have a mean diameter ranging from 400 nm to 1.5 μm, and comprise a respective shell comprising calcium, phosphate, water, magnesium, and strontium, and
- wherein:
- a Ca:P atomic ratio is 0.9-1.3;
- a Sr2+ content is 1-6 wt %;
- a Mg2+ content is 5-10 wt %;
- and
- a Ca2+ content is 15-25 wt %.
A method of treating or preventing caries and/or dentin hypersensitivity and/or enamel demineralization or decalcification defects in a subject, the method comprises administering a composition comprising a paste-forming compound and hollow calcium phosphate particles to a surface of at least one tooth of the subject, wherein the hollow calcium phosphate particles have a mean diameter ranging from 400 nm to 1.5 μm, and comprise a respective shell comprising calcium, phosphate, water, magnesium, and strontium, and
- wherein:
- a Ca:P atomic ratio is 0.9-1.3;
- a Sr2+ content is 1-6 wt %;
- a Mg2+ content is 5-10 wt %;
- and
- a Ca2+ content is 15-25 wt %.
Dependencies are inferred from the claim text.