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US 2026/0284661 A1Published application
Device and process for recovering organelle vesicles from cells, using a microfluidic extraction unit
AssigneesParis Sciences Et Lettres, Centre National De La Recherche Scientifique, Sorbonne Universite, Université Paris Cité
InventorsAbdou Rachid THIAM, Alexandre SANTINHO, Vincent FAUGERAS
Life of this patent
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Abstract
Device for recovering organelle vesicles from cells, including a microfluidic chip to extract organelle vesicles from cells, the microfluidic chip having one or more microchannels including one or more constriction portions. Process implementing such a device and extracellular organelle vesicles obtained by such a process.
Claims16
1-15. (canceled)
A device for recovering organelle vesicles from cells, comprising:
- an organelle swelling unit configured to constitute swelled intracellular organelle vesicles, and
- an extraction unit configured to extract swelled organelle vesicles from cells, said extraction unit comprising a microfluidic chip having one or more microchannels configured to receive a fluid flow containing said cells, said microchannels comprising one or more constriction portions configured to apply mechanical constraints on said cells while passing therethrough.
A process for recovering organelle vesicles from cells, comprising:
- a step of swelling said organelle vesicles with an organelle swelling unit of a device according to claim 1, and
- a step of extraction of swelled organelle vesicles from cells with an extraction unit of the device, and
- after the extraction step, a step of collecting said organelle vesicles with a collecting unit of the device.
Dependencies are inferred from the claim text.