Lateral flow immunoassay device with increased detection signal intensity and method for detecting target material using the same
AssigneePukyong National University Industry-University Cooperation Foundation
InventorsJoong Ho Shin, Se Been Park
Life of this patent
Estimating the term…
Abstract
The present invention provides an immunochromatography sensor cartridge comprising: a cover portion having a display portion formed therethrough so as to expose the measurement region of the immunochromatography sensor strip (hereinafter referred to as ‘strip’) to the outside; The cover portion or the support portion includes a solution blocking region forming portion for forming a blocking region by pressing or removing a predetermined region of the porous membrane adjacent to the measurement region exposed by the display portion by external pressure.
Claims6
A lateral flow immunoassay device with an increased detection signal intensity, wherein the device comprises:
- a sample pad for introducing a sample containing C-reactive protein (CRP) or SARS-COV-2 spike protein as a target material;
- a conjugate pad including a first conjugate bound with a marker;
- a porous membrane having a test line to which a second conjugate is immobilized and a control line to which a third conjugate is immobilized, the test line and control line being spaced apart;
- and
- an absorption pad,
- wherein a region of the porous membrane located between the test line and the control line is compressed to have a reduced pore size relative to regions of the porous membrane upstream of the test line and downstream of the control line, the compression corresponding to application of a pressure of 20-110 kgf during manufacture of the device.
Dependencies are inferred from the claim text.