Simultaneous mri and ultrasound guidance for histotripsy systems and methods
OwnerZhen XU, Timothy L. HALL +2inventors
InventorsZhen XU, Timothy L. HALL, Douglas NOLL, Jonathan R. SUKOVICH
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Abstract
A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Systems and methods are provided for performing transcranial histotripsy therapy of brain tissue. Features include systems and methods for monitoring the treatment and for correcting aberrations resulting from the ultrasound signals passing through the skull.
Claims22
An MRI compatible histotripsy system, comprising:
- a transducer array comprising a plurality of transducer elements;
- transmission circuitry coupled to the transducer array and configured to transmit histotripsy pulses into a target tissue;
- a MRI system configured to generate MR images of a target tissue of the subject;
- and
- one or more coils placed between the MRI system and a subject, the one or more coils being configured to receive MRI signals from the MRI system to improve an image signal-to-noise-ratio (SNR) of the MR images of the MRI system.
A transcranial ultrasound treatment system, comprising:
- a magnetic resonance (MR)-compatible histotripsy therapy array;
- a MR-compatible mechanical positioner with translation and rotation mobility configured to move the histotripsy therapy array;
- a stereotactic frame configured to rigidly fix a patient's head and facilitate aberration correction;
- an acoustic coupler acoustically coupled to the histotripsy therapy array to provide for ultrasound transmission from the histotripsy therapy array to the patient's head;
- and
- a support structure configured to connect the MR-conditional mechanical positioner with the histotripsy therapy array and to support the patient's neck.
-31. (canceled)
Dependencies are inferred from the claim text.