Portable Hydrogel Electrochemical Device for Skin Disease Treatment

A system for generating and delivering molecular hydrogen, comprising:

• a) an electrochemical cell comprising:
• a hydrogel,
• a membrane electrode assembly (MEA) embedded in the hydrogel, the MEA having a first mesh electrode and a second mesh electrode, and
• a proton exchange membrane (PEM) disposed between the first mesh electrode and the second mesh electrode;
• b) an adhesive coupled with a first side of the electrochemical cell, wherein the adhesive secures the electrochemical cell to a tissue of a subject;
• and
• c) a wireless electronic circuit coupled to the electrochemical cell on a second side opposite the first side of the electrochemical cell.

A method for generating, storing, and delivering molecular hydrogen (H2) to a tissue of a subject, the method comprising:

• a) facilitating a hydrogen evolution reaction (HER) within an electrochemical cell to generate H2, the electrochemical cell comprising:
• a hydrogel,
• a membrane electrode assembly (MEA) embedded in the hydrogel, the MEA having a first mesh electrode and a second mesh electrode, and
• a proton exchange membrane (PEM) disposed between the first mesh electrode and the second mesh electrode;
• b) storing, within the hydrogel of the electrochemical cell, the generated H2;
• c) regulating delivery of the stored H2 from the hydrogel to a tissue of the subject using a wireless electronic circuit attached to the electrochemical cell.