Intranasal and olfactory delivery devices and methods of use

A method for intranasal delivery of a composition to a target region of a nasal cavity of a subject, the method comprising:

• a. inserting a dispensing element into an ejection zone of the nasal cavity, wherein the ejection zone is:
• i. 0 mm to 30 mm superior to a horizontal line that intersects an anterior aspect of an internal nasal valve, and
• ii. 0 mm to 20 mm anterior to an inclined line that intersects an anterior aspect of a middle turbinate and a posterior aspect of a vestibule, and one or more of the following:
• 1. 0 mm to 40 mm inferior to a horizontal line that is parallel to an inferior aspect of an olfactory cleft,
• 2. 0 mm to 20 mm posterior to an internal nasal dorsum,
• 3. 10 mm to 50 mm superior to a horizontal line that intersects an inferior aspect of a columella,
• 4. 0 mm to 30 mm superior to a horizontal line that intersects a superior aspect of an inferior turbinate, and
• 5. 0 mm to 3 mm from a septum;
• b. dispensing the composition from the dispensing element to contact the target region with the composition.