Methods employing gaseous nitric oxide for inhibiting tumor growth
AssigneeBeyond Air, Inc.
InventorsHila Confino, Steven A. Lisi, Rinat Kalaora, Amir Avniel
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Abstract
Methods of inhibiting growth of cells or tissue of a primary and/or secondary tumor, and/or of stimulating an immunological response to the tumor, in a subject in need thereof, and systems for performing same, are provided. The methods employ local administration of a gas, such as gaseous nitric oxide, typically at a high dose. Immune cells obtained upon treating a tumor with gaseous nitric oxide, either in vivo or ex vivo, and methods employing same are also provided.
Claims20
A method of inhibiting growth of cells or tissue of a primary and/or secondary tumor in a subject in need thereof, the method comprising administering to the subject gaseous nitric oxide (gNO) and an anti-cancer therapy, wherein the gNO is administered by intratumoral injection at a dose of from about 1,000 ppm to about 1,000,000 ppm for a time period of from about 1 second to about 60 minutes at a volumetric flow of from about 0.00001 LPM to about 1 LPM.
A method of inhibiting growth of cells or tissue of a primary and/or secondary tumor in a subject in need thereof, the method comprising administering to the subject gaseous nitric oxide (gNO), wherein the gNO is administered by intratumoral injection at a dose of from about 20,000 ppm to about 200,000 ppm for a time period of from about 30 seconds to about 30 minutes at a volumetric flow of from about 0.00001 LPM to about 0.1 LPM.
Dependencies are inferred from the claim text.