Transdermal drug delivery devices and methods

A system for transdermal delivery of a drug formulation comprising:

• a transdermal membrane;
• a drug cartridge including:
• a sealed reservoir configured to hold a drug formulation therein;
• a breaking element configured to break the sealed reservoir upon actuation;
• an actuator disposed on a first side of the sealed reservoir configured to activate the breaking element to break the sealed reservoir;
• and
• a pressurizing element configured to place pressure on a second side the sealed reservoir opposite the first side such that, upon activation of the breaking element, drug formulation from the sealed reservoir is forced out of the sealed reservoir and onto the transdermal membrane;
• and
• a control unit having a battery and a printed circuit board for actuation of the actuator.