US 2026/0284284 A1 · DIALYSIS SYSTEM FOR TREATING SEPSIS

Dialysis system for treating sepsis

AssigneesMexbrain, Universite Claude Bernard Lyon 1, Centre National de la Recherche Scientifique (CNRS), Inserm (Institut National De La Sante Et De La Recherche Medicale), Institut Gustave Roussy, Vetagro-Sup Institut D'Enseignement Superieur Et De Recherche

InventorsMarco NATUZZI, Thomas BRICHART, Fabien ROSSETTI, Matteo MARTINI, François LUX, Olivier TILLEMENT, Jean-Luc PERFETTINI, Vanessa LOUZIER, Jeanne-Marie BONNET-GARIN, Jean-Yves AYOUB

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Abstract

Oxidative stress in a patient is reduced using a dialysis system. The dialysis system has a porous membrane and a vessel containing dialysis fluid with an additive therein that is polymeric and which has a size larger than the cutoff threshold of the membrane. In addition the additive contains at least one ligand specific for metal cations that circulated in the blood. The dialysis system can be used for treating sepsis caused by bacterial, parasitic, fungal or viral infections.

Claims9

Dependent claims

A method for reducing oxidative stress in a patient having need thereof, said method comprising operating a dialysis system comprising

(a) a porous dialysis membrane, and
(b) a vessel containing a dialysis fluid, wherein the dialysis fluid contains an additive selected from polymers, said additive having a size greater than the cutoff threshold of said porous dialysis membrane, and contains or is constituted of at least one ligand specific to metal cations circulating in the blood,
wherein said patient is suffering from sepsis or viral infection.

Dependencies are inferred from the claim text.