Vaginal Drug Delivery Device
AssigneeOak Crest Institute of Science
InventorsMarc M. Baum, John A. Moss, Mark Gordon
Life of this patent
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Abstract
This disclosure relates to the use of an intravaginal device to deliver biologically active compounds at a controlled rate for an extended period of time and methods of manufactures thereof. The device is biocompatible and biostable, and is useful in patients (humans and animals) for the delivery of appropriate bioactive substances to tissues or organs.
Claims44
A vaginal implant device configured to provide sustained drug delivery to a patient, the vaginal implant device comprising:
- a scaffold comprising one or more lobes and one or more hinge regions disposed between the one or more lobes;
- one or more cassettes disposed within the one or more lobes, respectively;
- and
- one or more active pharmaceutical ingredients (APIs) disposed within the one or more cassettes, respectively.
A vaginal implant device configured to provide sustained drug delivery to a patient, the vaginal implant device comprising:
- a scaffold comprising one or more lobes;
- one or more cassettes disposed within the one or more lobes, respectively;
- and
- one or more active pharmaceutical ingredients (APIs) disposed within the one or more cassettes, respectively,
- wherein each of the one or more cassettes is defined by a cap and a base coupled to the cap, further comprising a reservoir defined between the cap and the base of each of the one or more cassettes, wherein the one or more APIs are disposed within the reservoir of each of the one or more cassettes, and
- wherein each of the one or more cassettes comprises a membrane disposed in the reservoir of each of the one or more cassettes, wherein each cap comprises one or more first holes that expose the respective membrane to vaginal fluid of the patient.
A vaginal implant device configured to provide sustained drug delivery to a patient, the vaginal implant device comprising:
- a scaffold comprising one or more lobes;
- one or more cassettes disposed within the one or more lobes, respectively;
- and
- one or more active pharmaceutical ingredients (APIs) disposed within a reservoir of the one or more cassettes, respectively;
- wherein each of the one or more cassettes comprises a cap and a base coupled to the cap, thereby defining the reservoir, either (i) each cap having one or more first holes, one or more first ribs carried by one or more edges of the cap, and one or more pins, and each base having an angled lip, one or more second holes disposed opposite the one or more pins of the cap, and one or more second ribs carried by one or more edges of the base, or (ii) each base having one or more first holes, one or more first ribs carried by one or more edges of the base, and one or more pins, and each cap having an angled lip, one or more second holes disposed opposite the one or more pins of the base, and one or more second ribs carried by one or more edges of the cap, and
- wherein each of the one or more cassettes further comprises a membrane disposed between the base and the cap, wherein the one or more first holes of each cap or base expose the respective membrane to vaginal fluid of the patient,
- wherein the one or more pins of each cap or base are sized to be disposed in the one or more second holes of each respective base or cap,
- wherein each of the lobes of the scaffold comprises one or more first grooves and one or more second grooves, wherein the one or more first ribs of each cap or base are sized to be disposed in the respective one or more first grooves,
- wherein the one or more second ribs of each base or cap are sized to be disposed in the respective one or more second grooves, and wherein the angled lip of each base or cap is configured to aid alignment of the respective membrane between the base and the cap.
Dependencies are inferred from the claim text.