Hyaluronic acid compositions with low extents of ester linkages and methods of use thereof
AssigneeProhibix LLC
InventorBrendan Purcell
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Abstract
Compositions comprised of hyaluronic acid with low extents of ester linkages are disclosed. The compositions may enable longer half-lives of hyaluronic acid delivered in tissues throughout the body to prolong mechanical effects through controlled swelling and solubilization of hyaluronic acid as ester crosslinks between hyaluronic acid polymers hydrolyze. The compositions may also enable longer half-lives of medicaments or drugs in tissues throughout the body as ester linkages between the medicaments or drugs and hyaluronic acid polymers or networks hydrolyze. Compositions may include acrylate modified hyaluronic acid with low degrees of acrylate modification in order to preserve the physical properties of hyaluronic acid in the body.
Claims20
A composition comprising hyaluronic acid and a medicament, wherein the hyaluronic acid is conjugated with the medicament via ester bonds, and the composition is made by reacting acrylate modified hyaluronic acid with a chemical linker or the medicament.
A composition comprising a hyaluronic acid hydrogel, wherein crosslinks of the hyaluronic acid hydrogel include ester bonds, wherein the extent of crosslinking of the hyaluronic acid hydrogel is less than 5 percent, preferably between 0.01 to 5.0 percent, and more preferably at or between any two of 0.1, 0.5, 1.0, 2.0, 3.0, 4.0 or 5.0 percent.
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A composition comprising a hydrogel network and linked medicaments or drugs, wherein hydrogel crosslinks and medicament or drug linkages include ester bonds.
Dependencies are inferred from the claim text.