Medical devices for delivering one or more agents and methods of use and manufacture
AssigneeEncompass Vascular, Inc.
InventorsJean C. ORTH, Zaya TUN, Robert G. QUINTOS, Vu A. LAM
Life of this patent
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Abstract
Medical devices and methods for fluid delivery. In some uses, the devices are used in methods that include scoring a bodily lumen with expandable spines of an expandable scoring device. In some uses, the devices are used to deliver therapeutic agents through a plurality of needles and deliver anesthetic agents.
Claims19
A method of delivering an anesthetic agent in combination with a fluid agent with an intravascular delivery device comprising:
- advancing an intravascular apparatus to a target location within a lumen, the apparatus including an inflatable balloon and an expandable infusion scaffold that includes a plurality of primary spines, the plurality of primary spines each including at least first and second radial openings through the primary spine;
- inflating the balloon to cause the plurality of primary spines to move toward a wall of the lumen;
- delivering an anesthetic agent with the intravascular apparatus to a wall of the lumen;
- deploying at least first and second needles from the at least first and second radial openings in the primary spines and into the lumen wall;
- and
- delivering a fluid agent from the at least first and second needles associated with each of the plurality of primary spines into the lumen wall.
A method of scoring a lumen wall with a balloon-based intravascular fluid delivery device comprising:
- advancing an intravascular apparatus to a target location within a lumen, the apparatus including an inflatable balloon and an expandable infusion scaffold that includes a plurality of scoring spines, each of the plurality of scoring spines including a plurality of radial openings through the scoring spine;
- inflating the balloon to cause the plurality of scoring spines to expand and score the lumen wall;
- at a time subsequent to scoring the lumen wall, deploying at least first and second needles from radial openings in each of the plurality of scoring spines to penetrate the internal and/or external elastic lamina;
- and
- delivering a fluid agent from the at least first and second needles associated with each of the plurality of scoring spines into the lumen wall.
A method of scoring a lumen wall with a balloon-based intravascular fluid delivery device comprising:
- delivering an inflatable balloon in an unexpanded state and an expandable infusion scaffold in an unexpanded state disposed about the balloon to a location within a vessel, the expandable infusion scaffold comprising a plurality of infusion spines extending along at least a portion of the inflatable balloon, the infusion spines each having a plurality of radial openings therein;
- expanding the balloon radially outward by delivering an inflation fluid to a volume within the balloon, wherein expanding the balloon expands the plurality of infusion spines radially outward and causes the plurality of infusion spines to move towards and into contact with an inner wall of the vessel;
- dilating the vessel wall as the balloon expands radially;
- scoring the vessel wall as the infusion spines press against the vessel wall;
- deploying a plurality of needles from the radial openings in each of the plurality of infusion spines and through the vessel wall;
- delivering a therapeutic agent through the plurality of needles and into the vessel wall;
- retracting the needles into the openings in each of the plurality of infusion spines;
- collapsing the balloon-based intravascular fluid delivery device;
- and
- removing the balloon-based intravascular fluid delivery device from the vessel.
Dependencies are inferred from the claim text.