Method for fabrication and modulation of extracellular matrix biomaterials
AssigneeThe Chinese University of Hong Kong
InventorsDan WANG, Rocky Sung Chi TUAN, Dai Fei Elmer KER, Shu Ting HUANG, Yang XU
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Abstract
Provided herein are graft materials particularly suitable for use to repair tendon defects including massive rotator cuff tendon defects. The provided graft materials have a hybrid core-shell structure, where the shell includes a photocrosslinkable hydrogel and an extracellular matrix, and where the core includes an elastomeric polymer covalently crosslinked to the shell. Also provided are methods of producing the disclosed graft materials, and methods of using the graft materials to repair a tendon defect.
Claims22
A graft material comprising:
- a shell comprising a photocrosslinkable hydrogel and an extracellular matrix;
- and
- a core comprising an elastomeric polymer covalently crosslinked to the shell.
A method of producing a graft material, the method comprising:
- providing an extracellular matrix;
- forming a pre-hydrogel mixture comprising a photocrosslinkable polymer and the extracellular matrix;
- providing an elastomeric polymer;
- absorbing a photocrosslinking agent onto a surface of the elastomeric polymer, thereby yielding a treated elastomeric polymer;
- applying the pre-hydrogel mixture to the treated elastomeric polymer, thereby creating a pre-graft material;
- and
- irradiating the pre-graft material with ultraviolet light for an exposure duration, thereby producing the graft material.
Dependencies are inferred from the claim text.