Flowable sealant composition based on rapid gelling hydrogel precursors and particulate hydrogels; procedures based on the sealant compositions

Abstract

Compositions, methods, and applications for flowable, particulate-containing compositions with rapid gelling hydrogel precursors are described. The compositions are effective and convenient for forming hydrogels at target tissue locations, with the hydrogels facilitating hemostasis of tissue defects, tissue sealing, and/or space filling, for example. Compositions having entrapped gas can enable high accuracy of delivery to target tissue locations. The compositions can be applied using various delivery vehicles, including syringes and cannulas. Methods for forming the compositions and delivery of the compositions are described. The compositions can be useful for treating fistulas.

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