Humanised antibodies and uses thereof

A method of treating a subject with a cytotoxic agent, the method comprising:

• administering a cytotoxic agent to a subject, or providing a subject who has been administered a treatment with a cytotoxic agent,
• administering an antigen binding protein as described herein to the subject, wherein the antigen binding protein comprises a detectable moiety for enabling detection thereof,
• detecting the antigen binding protein in the subject,
• determining to continue or continuing to administer the cytotoxic agent to the subject when the detection of the antigen binding protein in the subject is above a background level;
• or
• determining to discontinue or discontinuing to administer the cytotoxic agent to the subject when the detection of the antigen binding protein in the subject is the same or lower than a background level, optionally determining to administer or administering an increased dose of the cytotoxic agent or an alternative or supplemental treatment to the subject.

A method of treating a subject with a cytotoxic agent, the method comprising:

• administering a cytotoxic agent to a subject, or providing a subject who has been administered a treatment with a cytotoxic agent,
• administering an antigen binding protein as described herein to the subject, wherein the antigen binding protein comprises a detectable moiety for enabling detection thereof,
• detecting the antigen binding protein in the subject,
• determining to continue or continuing to administer the cytotoxic agent to the subject based on the output of a machine learning model or algorithm indicating the presence or increased presence of La antigen in the subject;
• determining to discontinue or discontinuing to administer the cytotoxic agent to the subject based on the output of a machine learning model or algorithm indicating an absence of La antigen in the subject, optionally determining to administer or administering an increased dose of the cytotoxic agent or an alternative or supplemental treatment to the subject.

A method of treating, preventing or minimising progression of a disease or condition, preferably of cancer, in a subject, minimising, reducing or preventing growth of a tumor in a subject, minimising, reducing or preventing metastasis in a subject, or increasing survival of a subject, the method comprising:

• providing a subject who has received a first cytotoxic therapy;
• and
• administering to the subject, a second cytotoxic therapy in the form of an antigen binding protein as described herein, wherein the antigen binding protein is conjugated to, or associated with, a cytotoxic agent,
• thereby treating, preventing or minimising progression of a disease or condition, preferably of cancer, in a subject;
• or minimising, reducing or preventing growth of a tumour in a subject, or minimising, reducing or preventing metastasis in a subject, or increasing survival of a subject.