Gastrin-releasing peptide receptor (grpr)-targeted compounds and uses thereof

A compound of Formula (I),

• (I)
• Rradn6-[linker]-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-
• Xaa7-Xaa8-[ψ-Xaa9-(Xaa10)m2]m1-R
• or a salt thereof, wherein:
• Xaa1 is an N-terminal amino acid residue selected from D-Phe, D-Cpa, D-Nal, or D-2-Nal;
• Xaa2 is Asp, Asn, Gln, or Glu;
• Xaa3 is Trp, Trp(Me), αMe-Trp, Trp(7-F), Trp(6-F), Trp(5-F), or Trp(4-F);
• Xaa4 is Ala or D-Ala;
• Xaa5 is Val or tert-leucine (Tle);
• Xaa6 is Gly or D-Ala;
• Xaa7 is Trp, Trp(Me), Trp(7-Me), Trp(6-Me), Trp(5-Me), Trp(4-Me), Trp(2-Me), Trp(7-F), Trp(6-F), Trp(5-F), Trp(4-F), Trp(7-Cl), Trp(6-Cl), Trp(5-Cl), Trp(4-Cl), Trp(7-Br), Trp(6-Br), Trp(5-Br), Trp(4-Br), Trp(7-I), Trp(6-I), Trp(5-I), Trp(4-I), Trp(5-OH), or αMe-Trp;
• Xaa8 is Leu;
• m1 is 1 and m2 is 0;
• Xaa9 is Pro, oxazolidine-4-carboxylic acid (4-oxa-L-Pro), or 4,4-difluoroproline (difluoroPro);
• R is —NH2;
• ψ represents a peptide bond or reduced peptide bond joining Xaa8 to Xaa9;
• the linker comprises p-aminomethylaniline-diglycolic acid (pABzA-DIG), 4-amino-(1-carboxymethyl)piperidine (Pip), 9-amino-4,7-dioxanonanoic acid (dPEG2), or 4-(2-aminoethyl)-1-carboxymethyl-piperazine (Acp), wherein the linker optionally comprises an albumin binder;
• n6 is 1;
• Rrad is a radiometal chelator;
• wherein the compound is optionally bound by a radiometal;
• and
• wherein Xaa1, Xaa2, Xaa3, Xaa4, Xaa5, Xaa6, Xaa7, Xaa8, or Xaa9 is each optionally N-methylated.