Radiolabeled activated ester and precursor thereof
AssigneesInstitute of Science Tokyo, National University Corporation Chiba University, Taiyo Nippon Sanso Corporation
InventorsHiroshi TANAKA, Tomoya UEHARA
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Abstract
Provided as a precursor of a radioactive halogen-labeled compound is a compound represented by the following general formula (I): wherein, R1 represents a leaving group capable of nucleophilic substitution by a halide ion, R2 represents a leaving group such that nucleophilic acyl substitution reaction is advanced by an amino group, and R3 represents a hydrogen atom or a halogen atom.
Claims17
A compound represented by a following general formula (I):
- wherein, R1 represents a leaving group capable of nucleophilic substitution by a halide ion, R2 represents a leaving group such that nucleophilic acyl substitution reaction is advanced by an amino group, and R3 represents a hydrogen atom or a halogen atom.
A compound represented by a following general formula (IIa) or (IIb):
- wherein, X represents a radioactive halogen atom, R2 represents a leaving group such that nucleophilic acyl substitution reaction is advanced by an amino group, and R3 represents a hydrogen atom or a halogen atom.
A compound represented by a following general formula (IIIa) or (IIIb):
- wherein, X represents a radioactive halogen atom, R3 represents a hydrogen atom or a halogen atom, R4 represents a monovalent group derived from a physiologically active substance.
Dependencies are inferred from the claim text.